Select Our Next BRIght Futures Prize Winner!

Posted by Brigham and Women's Hospital October 14, 2016

Would you like to choose the direction of medical research? Select our next BRIght Futures Prize winner! The BRIght Futures Prizes support investigators across the Brigham Research Institute (BRI) as they work to answer challenging questions and solve grand problems in medicine. This year’s finalists, all Brigham and Women’s Hospital researchers and clinicians, were selected through a rigorous two-step scientific review process. Their projects include an innovative home hospital concept, a new way to predict and treat Alzheimer’s disease, and a novel ultrasound device for ulcerative colitis.

Your vote will help decide which of this year’s three finalists will receive the $100,000 research prize. To participate, watch the video below, read the Q&A with the finalists, and then cast your vote. The winner will be announced on November 10, 2016 at Discover Brigham. This event is free and open to the public. All are welcome to attend!

 

 

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New Way to Study Alzheimer’s Disease

Posted by Brigham and Women's Hospital April 1, 2014

New Way to Study Alzheimer's Disease

This image illustrates neurons derived from stem cells of a living patient with a genetic predisposition to Alzheimer’s disease. Neuronal protein is shown in green. Red depicts a subset of neurons affected in the disease process.

Using cells from blood relatives with familial Alzheimer’s disease (AD), a team of researchers at Brigham and Women’s Hospital (BWH) has been able to study the underlying causes of AD and develop new ways to test treatment approaches.

People with familial AD have a genetic predisposition that leads to early development of the disease. More than 200 different mutations are associated with familial AD. Depending on the mutation, patients with familial AD can begin exhibiting symptoms as early as their 30s and 40s.

“Our research using human cells affected by AD has been limited to tissue samples from patients who have already died from the disease,” says Dr. Tracy L. Young-Pearse, corresponding author of the study recently published in Human Molecular Genetics and an investigator in the BWH Center for Neurologic Diseases. “AD is characterized by the presence of amyloid-beta protein plaques and Tau protein tangles, but observing living cell behavior and understanding the role of these abnormal protein deposits and tangles and their relationship has been challenging.”

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