Groundbreaking Alzheimer’s Trial Featured on CBS News

Posted by Brigham and Women's Hospital March 26, 2015

Reisa A. Sperling, MD

Helene lost her mother to Alzheimer’s. Now, her sister is battling the disease. While Helene is not showing symptoms, scans of her brain show the buildup of amyloid plaques that are believed to lead to the development of Alzheimer’s.

CBS News interviewed Helene, who is participating in a groundbreaking international clinical trial that is the first to examine early treatment of older adults at risk for Alzheimer’s disease – with the hope of preventing memory loss before it begins. Led by Dr. Reisa Sperling, Director of the Center for Alzheimer Research and Treatment at Brigham and Women’s Hospital, the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease (A4) Study is for people without symptoms, but whose brain scans show the buildup of amyloid plaques. The A4 study is currently enrolling 1,000 participants at 60 sites in the United States, Canada, and Australia. To learn more about the A4 study and other studies for Alzheimer’s disease, please contact the BWH Center for Alzheimer Research and Treatment.

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A Quest to Preserve Memories: Alzheimer’s Research

Posted by Brigham and Women's Hospital September 17, 2013

In observance of World Alzheimer’s Month, we’ve gathered recent posts about the work of our physicians who are leading research to understand and develop new treatments for Alzheimer’s disease.


New Approaches for Treating Alzheimer’s Disease

Dr. Reisa Sperling believes that earlier treatment, prior to development of symptoms, is key to helping people with Alzheimer’s disease. This approach is consistent with how we’ve made progress against other diseases, such as reducing cholesterol to prevent heart disease. Learn how Dr. Sperling is applying this approach to Alzheimer’s disease.


Genetic Culprit Identified in Progression of Alzheimer’s

Thanks to some intercontinental teamwork, researchers have identified a gene that may help explain why certain Alzheimer’s disease patients experience a more rapid decline in cognitive (thinking) abilities.



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